10 Ways to Stimulate Collagen Production in Mature Skin

Have you noticed the lines around your eyes seem a bit deeper lately? Do your cheeks feel less supple than they used to? This is likely due to a natural decline in collagen, the protein responsible for our skin's plumpness.

This loss can be disheartening cause it's a sign of aging we'd rather avoid. But there's hope. By incorporating some simple strategies into your routine, you can fight back against this depletion.

What is collagen?

Collagen, the most abundant protein in the body, plays a critical role in youthful skin. It provides the structural support that gives it elasticity while also hydrating.

When you reach your mid-20s, its production starts decreasing around 1% annually. But the decline isn't solely due to aging. Genetics, sun exposure, smoking, overall lifestyle choices, and hormonal fluctuations can all significantly impact the process.



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Dietary and lifestyle factors

• Exercise can also benefit collagen by improving blood flow, reducing stress, and regulating hormones.
• Smoking, on the other hand, hinders collagen production by causing inflammation and promoting collagen breakdown. [1]
• Vitamin C, found in citrus fruits, berries, and leafy greens, is essential for collagen synthesis. Vitamin E, zinc, and amino acids from protein may also contribute.

InsideTracker Ultimate Plan analyzes your bloodwork, revealing deficiencies in Vitamin D. It can also examine magnesium, which relates to skin elasticity and hydration

Based on your results, InsideTracker provides personalized recommendations for making changes to address any shortages.

1. Chemical peels

Chemical peels remove damaged outer layers of skin, prompting the growth of new, smoother skin to replace them. Different types are available for various concerns, such as wrinkles or acne, and the depth of the procedure affects the results and recovery time. [2]

A study in the Journal of Cosmetic Dermatology tested a specific chemical peel to treat mild to moderate facial aging. [3] The researchers combined 6% trichloroacetic (TCA) and 12% lactic acid. The participants improved skin texture, brightness, fine lines, and clarity.

Most importantly, people with various skin tones tolerated it well, which suggests it could be suitable for more sensitive skin. The approach could be a gentler alternative to resurfacing techniques like laser treatment if you're worried about side effects or cost.

Chemical peels come in different depths, targeting various skin concerns. Ligther ones buff away the top layer for a brighter complexion.



2. Microneedling

This minimally invasive treatment uses a device with tiny needles to create micro-injuries in the top layer of the skin. The controlled injury triggers the body's healing process, leading to increased collagen production and improved texture.

A review published in the Journal of Dermatologic Surgery confirmed that this method is effective. [4] It can address aging and several different conditions, including acne scars, rhytides, and striae.

Microneedling offers faster healing times compared to other skin resurfacing treatments like lasers or chemical peels.



3. Retinoids

Derived from Vitamin A, retinoids are powerful anti-aging ingredients that stimulate and break down existing collagen. They can also be effective for wrinkles, sun damage, and uneven skin tone.

Tretinoin, a prescription version of retinoid could be the most effective. But, researchers are still developing new delivery methods to improve the effectiveness of these products. [5]

Retinoids also help unclog pores and regulate cell turnover, reducing breakouts and promoting clearer skin.



4. Vitamin C

Vitamin C is a potent antioxidant that helps produce new and protects existing collagen from sun damage and environmental aggressors. Most people use it in the form of serum for a smoother, brighter skin.

Studies suggest vitamin C might be effective in treating signs of sun damage—photoaging—in sensitive skin. In one of them, researchers administered its biologically active form called abscorbic acid in two ways. [6]

The first one, sonophoresis, used ultrasound to drive molecules deep while the other used microneedlings. Both methods improved elasticity and reduced the redness, especially microneedling on the cheeks. The subjects had no side-effects, so this approach could be suitable for sensitive people.

Vitamin C helps inhibit melanin production, which can reduce hyperpigmentation, sun spots, and leave you with a more even skin tone.



5. LED light therapy

LED therapy is a noninvasive treatment for collagen stimulation available at spas or for home use. A study tested the effectiveness of a specific LED mask emitting red light at 630nm for 12 minutes twice a week for three months.

Researchers studied 20 healthy Caucasian women, measuring skin laxity, firmness, elasticity, texture, and oiliness. [7] Participants saw improvements in all measured aspects.

Plus, positive effects lasted for up to one month after stopping treatment. The study suggests that this approach can be an effective and lasting way to address visible signs of facial aging.

LED devices emit specific light wavelengths that different layers of the skin absorb..



6. Dermal fillers

These injectable products, commonly made of hyaluronic acid, add volume and plumpness to areas with lost collagen. [8] They provide immediate results by filling wrinkles and lines, but they also stimulate natural collagen production over time.

A review of studies investigated the effects of this approach. Based on limited studies examined, permanent and semi-permanent injections improved appearance more than temporary options. In the short term, the method appears safe, but we lack data for the longitudinal effects.

A thorough consultation with a qualified healthcare professional is crucial to discuss your goals, assess suitability, and choose the appropriate filler type.



7. Fractional laser therapy

This treatment uses targeted laser beams to create microscopic columns of injury in specific areas of the skin. The controlled damage triggers collagen production, leading to improved texture and reduced wrinkles.

A review examined 25 studies—including trials and case series—to assess FRF's effectiveness and safety for wrinkle reduction and tightening. Participants had varying skin types and wrinkle severity. [9]

While most studies reported improvement with FRF, they were generally small and lacked strong methodology. Common side effects were mild pain, redness, and swelling, with some cases of hyperpigmentation.

But, significant variation in details across studies limited comparisons. While FRF shows promise, high-quality research with standardized protocols is necessary to confirm its anti-aging efficacy.

The treatment can address sun damage like sunspots, uneven skin tone, and hyperpigmentation.



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8. Topical ingredients

Several topical ingredients can also work alongside these treatments to further support collagen production:

Peptides

As skin ages due to sun damage and environmental factors, these components can help combat the free radicals that contribute to wrinkles. These short chains of amino acids act as messengers, signaling the production of more collagen. [10]

Glycolic (GA) and alpha hydroxy (AHA) acids

These exfoliating acids remove dead skin cells and may indirectly stimulate collagen production by promoting cell turnover. For example, a study investigated the effect of AHAs on the face. After three weeks, the participants had reduced wrinkles and improved roughness and elasticity.

GA also combats signs of aging, but high amounts can cause irritations. A study examined how various concentrations (8–25%) of it affect human skin samples. [11]

It found that partially neutralized GA formulations (pH 4) at all concentrations increased skin cell shedding. They also boosted collagen production without causing inflammation. The results suggest these mixtures could be effective for rejuvenation while being gentler.

Niacinamide

Vitamin B3 deficiency can cause serious health problems. Nicotinamide, a form of Vitamin B3, helps our cells function properly and protects them from damage. Studies show that applying nicotinamide to the skin can reduce wrinkles, hyperpigmentation, and improve overall skin health. [12]

While the exact mechanism isn't fully understood, it's likely beneficial because it helps maintain skin cells' health and reduces inflammation. This makes nicotinamide a promising ingredient in anti-aging and lightening products, especially for older adults.



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9. Ultrasound therapy

Ultrasound therapy uses focused energy. Unlike lasers, it avoids damaging the skin's surface and focuses on the deep tissue. This controlled heating stimulates collagen production, leading to a tighter appearance. [13]

The technology is approved for lifting lax skin on the neck, chin, and brow areas. An additional benefit is the ability to visualize the treatment area during the procedure, ensuring precision.

Ultrasound bypasses the surface of the skin and delivers focused energy deep into the dermis, where collagen resides.



10. Facial massage

Massage can improve blood circulation, bringing nutrients and oxygen to the skin cells. It might also create a more favorable environment for collagen production by stimulating fibroblasts. But the exact mechanism and how much stimulation is needed remain unclear.

When gently massaged, skin tissue firms up and produces more proteins like collagen and elastin, which are important for youthful skin. Researchers found the most effective frequency to be 75Hz in a lab setting. [14]

In a human trial, women who used a massage device with their anti-aging cream saw more significant improvement in wrinkles and skin texture compared to those who used just the cream.

Some massage techniques aim to drain lymph fluid, which can reduce puffiness and potentially improve overall skin health.



Potential side effects

Collagen-boosting ingredients like retinoids and AHAs can irritate and redden skin. Some may increase sun sensitivity. Patch test new products to avoid allergic reactions. Start potent ingredients gradually.

For deeper concerns, consider professional treatments like laser therapy or fillers, but be aware of potential risks like scarring and infection from these procedures.

Reveal your youthful glow

While aging is inevitable, there are steps you can take to encourage your body's natural collagen production and maintain a youthful look. Minimally invasive spa treatments seem like a viable option but consult your dermatologist first.

By assessing various biomarkers related to hormones, sleep, and metabolism, InsideTracker provides a holistic picture of your health. Maintaining a balanced and healthy body often reflects positively on skin health.

You'll get science-backed recommendations to improve your healthspan—the number of years you can live feeling your best. Remember, consistency is essential, so find a routine that works for you and embrace a holistic approach to keeping your skin glowing.

References:

[1] “Cigarettes Smoking and skin: A comparison study of the biophysical properties of skin in Smokers and Non-Smokers,” PubMed, Feb. 01, 2019. Available: https://pubmed.ncbi.nlm.nih.gov/32440305/

[2] “Chemical peels for skin resurfacing,” PubMed, Jan. 01, 2024. Available: https://pubmed.ncbi.nlm.nih.gov/31613532/

[3] J. Fanning, C. Jacob, I. Diaz, and O. Ibrahim, “Treatment of mild‐to‐moderate facial cutaneous aging using a combination peel containing 6% trichloroacetic acid and 12% lactic acid,” Journal of Cosmetic Dermatology, vol. 22, no. 11, pp. 3033–3041, May 2023, doi: 10.1111/jocd.15814. Available: https://pubmed.ncbi.nlm.nih.gov/37227430/

[4] T. S. Alster and P. M. Graham, “Microneedling: A review and Practical guide,” Dermatologic Surgery, vol. 44, no. 3, pp. 397–404, Mar. 2018, doi: 10.1097/dss.0000000000001248. Available: https://pubmed.ncbi.nlm.nih.gov/28796657/

[5] D. Milosheska and R. Roškar, “Use of retinoids in topical antiaging treatments: A focused review of clinical evidence for conventional and nanoformulations,” Advances in Therapy, vol. 39, no. 12, pp. 5351–5375, Oct. 2022, doi: 10.1007/s12325-022-02319-7. Available: https://pubmed.ncbi.nlm.nih.gov/36220974/

[6] A. Jaros-Sajda, E. Budzisz, and A. Erkiert-Polguj, “Ascorbic acid treatments as effective and Safe Anti-Aging therapies for sensitive skin,” Antioxidants, vol. 13, no. 2, p. 174, Jan. 2024, doi: 10.3390/antiox13020174. Available: https://pubmed.ncbi.nlm.nih.gov/38397772/

[7] V. Couturaud, M. L. Fur, M. Pelletier, and F. Granotier, “Reverse skin aging signs by red light photobiomodulation,” Skin Research and Technology, vol. 29, no. 7, Jun. 2023, doi: 10.1111/srt.13391. Available: https://pubmed.ncbi.nlm.nih.gov/37522497/

[8] L. P. Sturm, R. D. Cooter, K. L. Mutimer, J. C. Graham, and G. J. Maddern, “A systematic review of dermal fillers for age‐related lines and wrinkles,” ANZ Journal of Surgery/ANZ Journal of Surgery, vol. 81, no. 1–2, pp. 9–17, Jan. 2011, doi: 10.1111/j.1445-2197.2010.05351.x. Available: https://pubmed.ncbi.nlm.nih.gov/21299793/

[9] I. A. Kleidona, D. Karypidis, N. Lowe, S. Myers, and A. Ghanem, “Fractional radiofrequency in the treatment of skin aging: an evidence-based treatment protocol,” Journal of Cosmetic and Laser Therapy, vol. 22, no. 1, pp. 9–25, Dec. 2019, doi: 10.1080/14764172.2019.1674448. Available: https://pubmed.ncbi.nlm.nih.gov/31825296/

[10] M. Liu et al., “Anti-ageing peptides and proteins for topical applications: a review,” Pharmaceutical Development and Technology, vol. 27, no. 1, pp. 108–125, Jan. 2022, doi: 10.1080/10837450.2021.2023569. Available: https://pubmed.ncbi.nlm.nih.gov/34957891/

[11] M. Narda, C. Trullas, A. Brown, J. Piquero‐Casals, C. Granger, and G. Fabbrocini, “Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF‐alpha in human skin explants,” Journal of Cosmetic Dermatology, vol. 20, no. 2, pp. 513–521, Jul. 2020, doi: 10.1111/jocd.13570. Available: https://pubmed.ncbi.nlm.nih.gov/32583600/

[12] A. C. Chen and D. L. Damian, “Nicotinamide and the skin,” Australasian Journal of Dermatology, vol. 55, no. 3, pp. 169–175, Mar. 2014, doi: 10.1111/ajd.12163. Available: https://pubmed.ncbi.nlm.nih.gov/24635573

[13] K. Minkis and M. Alam, “Ultrasound skin tightening,” Dermatologic Clinics, vol. 32, no. 1, pp. 71–77, Jan. 2014, doi: 10.1016/j.det.2013.09.001. Available: https://pubmed.ncbi.nlm.nih.gov/24267423/

[14] E. Caberlotto, L. Ruiz, Z. Miller, M. Poletti, and L. Tadlock, “Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles,” PloS One, vol. 12, no. 3, p. e0172624, Mar. 2017, doi: 10.1371/journal.pone.0172624. Available: https://pubmed.ncbi.nlm.nih.gov/28249037/